A 1.5L compared to a 1.6l is slightly more efficient, and unless the driver is constantly going near redline/peak power on the freeway, there won't be any drop in efficiency from using the smaller engine. But, the gain in efficiency isn't very large either, since we're talking about a 100cc difference in displacement. I bet having the tires 5-10psi under the sidewall spec would hit efficiency the same, if not more.
Regarding a larger V8 diesel, we could optimize it by having it idle down the freeway, but these are really small cars, so even at idle, the V8 diesel probably wouldn't be able to use enough fuel to compete with the smaller diesel unless the smaller diesel was completely wound out at the same speed. It's just too big, and given the small load required, probably wouldn't have very good efficiency. It'd still get ~30-40mpg, but I don't think it'd ever see 50mpg imo. A compromise would be an engine that's larger, but still small enough to run at high load with the right gearing. Something around 3.0L at ~1000-1500rpm at ~55mph. The TDIclub forum has some interesting posts about swapping in a taller 6th to increase mileage.
Load, in every BSFC map I've seen, is just expressed as torque, or pressure. It's the percentage of torque needed at whatever rpm. The key is rpm, since we're talking about fuel efficiency. Too high, and friction losses build up, too low and we may see other problems like oil pressure or a crappy spot in the BSFC thanks to a turbo (TDI map has this I think). Ideally, we can take map, like this on for the TDI

Or this one for a gasoline engine in one of my cars...

And find a point where the fuel consumption is smallest at some speed. But, we don't want to be upshifting every time we hit an uphill grade, so ~1/2-2/3rds of load at a proportionally lower rpm is a good rule of thumb. Granted, we may upshift more often, but the mileage increases, especially for a gasoline engine, can be huge. For instance, my engine is the dotted lines on the second map. If I can put in a custom OD gear that's half the ratio, my mileage will go from slightly over 30mpg@2000rpm@55mph, to slightly under 50mpg@1000rpm@55mph. A very nice increase. Otoh, the TDI won't see that big of an increase, but there's still something to be gained by taller gearing as well. And if we want to accelerate, we just down shift and take off... Course, most people expect "good" acceleration in all gears, and they wouldn't want to sacrifice "driveability for an extra 5-20mpg, so we don't see really tall OD gears on anything except muscle cars that are trying to avoid the gas guzzler tax (.5:1 sixth gear on a T56). And most economy cars come with CVTs, but it's still nice to know what's possible.And interesting tidbit, is that when making a car more efficient (lower Cd/Crr), we make the engine less efficient assuming the same gearing. This isn't so bad in a diesel, since engine efficiency drops linearly for the most part, but in a gasser, engine efficiency drops exponentially, so it's a definite 2 steps forward 1 step back deal.